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Collaboration › Details

Biotheus–Alligator Bioscience: therapeutic antibodies, 201908– license to Ab from Alligator-Gold library for bispecific molecules for Greater China


Period Period 2019-08-20
Region Region China
Organisations Partner, 1st Biotheus Inc. (CN)
  Partner, 2nd Alligator Bioscience AB (Nasdaq Stockholm: ATORX)
  Group Alligator Bioscience (Group)
Products Product therapeutic antibody
  Product 2 Alligator-Gold® synthetic svFv library

Alligator Bioscience AB. (8/20/19). "Press Release: Alligator Bioscience Signs Antibody Agreement for Greater China with Biotheus Inc.". Lund.

Alligator Bioscience (Nasdaq Stockholm: ATORX), today announces that a license agreement has been reached with Biotheus Inc. (“Biotheus”), a privately held Chinese company based in Zhuhai, Guangdong, China. Under the license agreement, Alligator has granted Biotheus rights in Greater China (including Republic of China, Hongkong, Taiwan and Macau) to an antibody from ALLIGATOR-GOLD® for the creation of up to three bispecific molecules. The license agreement includes an option for expanding the license to covering global rights.

The license agreement includes an upfront of USD 1 million where Alligator receives USD 0.5 million upon signing and USD 0.5 million after 6 months of scientific-technical evaluation. Under the agreement Alligator is eligible to receive upfront, milestones and option fees of up to a total of approximately USD 142 million. This sum includes upfront and development milestones amounting to a total of approx. USD 52 million, global option fees up to a total of USD 90 million, plus royalties on future sales and share of sub-license revenue.

“This agreement is a great recognition of our antibody library and our proven expertise in generating high affinity antibodies against TNFR family members, and this collaboration with an up and coming Chinese biotech firm like Biotheus gives us an entrance to the fast advancing life science market in China”, said Per Norlén, CEO Alligator Bioscience.

The Tumor Necrosis Factor Receptor super family (TNFR-SF) is a family of related receptors, sharing sequence homology. Several Alligator pipeline programs interact with members of the TNFR super family.

For further information, please contact:
Cecilia Hofvander, Director IR & Communications
Phone +46 46 540 82 06

This information is such information as Alligator Bioscience AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation. This information was submitted for publication, through the agency of the contact persons set out above, at 4:35 p.m. CEST on August 20, 2019.

About Biotheus Inc.

Biotheus is a fast-growing biotechnology company based in Zhuhai, Guangdong, China with expectations to expand to >60 employees by 2019. Biotheus’ management team has broad experience from drug discovery to NDA filing in China. Biotheus is developing a broad me-better/novel target pipeline focused on immuno-oncology and metabolic disease areas, with the aim to develop their leading assets towards market authorization. Biotheus is actively looking for late-stage clinical and commercialization partners to fulfill these aims.

About Alligator Bioscience

Alligator Bioscience AB is a clinical-stage biotechnology company developing tumor-directed immuno-oncology antibody drugs. Alligator’s growing pipeline includes five lead clinical and preclinical drug candidates: ADC-1013, ATOR-1015, ATOR-1017, ALG.APV-527 and ATOR-1144. Alligator’s shares are listed on Nasdaq Stockholm (ATORX). The Company is headquartered in Lund, Sweden, and has approximately 55 employees. For more information, please visit

Record changed: 2020-03-14


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